Dataset Information

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.

ABSTRACT:

Background

Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).

Methods

Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.

Results

The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).

Conclusion

Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

SUBMITTER: Sachdev PS

PROVIDER: S-EPMC4634954 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.

Sachdev Perminder S PS Lipnicki Darren M DM Kochan Nicole A NA Crawford John D JD Thalamuthu Anbupalam A Andrews Gavin G Brayne Carol C Matthews Fiona E FE Stephan Blossom C M BC Lipton Richard B RB Katz Mindy J MJ Ritchie Karen K Carrière Isabelle I Ancelin Marie-Laure ML Lam Linda C W LC Wong Candy H Y CH Fung Ada W T AW Guaita Antonio A Vaccaro Roberta R Davin Annalisa A Ganguli Mary M Dodge Hiroko H Hughes Tiffany T Anstey Kaarin J KJ Cherbuin Nicolas N Butterworth Peter P Ng Tze Pin TP Gao Qi Q Reppermund Simone S Brodaty Henry H Schupf Nicole N Manly Jennifer J Stern Yaakov Y Lobo Antonio A Lopez-Anton Raúl R Santabárbara Javier J

PloS one 20151105 11

<h4>Background</h4>Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).<h4>Methods</h4>Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.<h4>Results</h4>The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with a ...[more]

PMID: 26539987

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Dataset Information

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.

Background

Methods

Results

Conclusion

Publications

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration.

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