Ontology highlight
ABSTRACT:
SUBMITTER: Hjelm BE
PROVIDER: S-EPMC4635522 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Hjelm Brooke E BE Rollins Brandi B Mamdani Firoza F Lauterborn Julie C JC Kirov George G Lynch Gary G Gall Christine M CM Sequeira Adolfo A Vawter Marquis P MP
Molecular neuropsychiatry 20151028 4
Genetic evidence has supported the hypothesis that schizophrenia (SZ) is a polygenic disorder caused by the disruption in function of several or many genes. The most common and reproducible cellular phenotype associated with SZ is a reduction in dendritic spines within the neocortex, suggesting alterations in dendritic architecture may cause aberrant cortical circuitry and SZ symptoms. Here, we review evidence supporting a multifactorial model of mitochondrial dysfunction in SZ etiology and disc ...[more]