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Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.

ABSTRACT:

SUBMITTER: Williams HL 

PROVIDER: S-EPMC4643530 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.

Williams Hannah L HL   Mansell Steven S   Alasmari Wardah W   Brown Sean G SG   Wilson Stuart M SM   Sutton Keith A KA   Miller Melissa R MR   Lishko Polina V PV   Barratt Christopher L R CL   Publicover Steven J SJ   Martins da Silva Sarah S  

Human reproduction (Oxford, England) 20151008 12

<h4>Study question</h4>Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their functional significance for fertilization success?<h4>Summary answer</h4>Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF.<h4>What is known already</h4>In human spermatozoa, Ca(2+) influx induced by progesterone is mediated by CatSper,  ...[more]

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