Genetic polymorphisms of Trim5a are associated with disease progression in acutely and chronically HIV-infected patients.

ABSTRACT:

Background

The tripartite interaction motif 5a (Trim5a) plays critical roles in restricting various kinds of retroviruses in different species. It has been shown that Trim5a could inhibit HIV-1 inhibition in vitro.

Methods

In this study, 16 SNPs of Trim5a gene were screened in 236 acutely HIV-infected patients (169 common type (CT) patients and 67 patients with rapid disease progression). In addition, they were screened in 162 chronically HIV-infected patients (147 common type patients and 15 long-term non-progressors (LTNP)). The potential effects of polymorphisms at Trim5a genes on HIV-infection disease progression were analyzed.

Results

Among all tested SNP sites, 3 SNPs (rs3824949, rs2291841 and rs11038628) were identified to be associated with rapid disease progr

SUBMITTER: Sun X 

PROVIDER: S-EPMC4659023 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature