Ontology highlight
ABSTRACT:
SUBMITTER: Yanachkov IB
PROVIDER: S-EPMC4674339 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20151109
Currently approved platelet adenosine diphosphate (ADP) receptor antagonists target only the platelet P2Y12 receptor. Moreover, especially in patients with acute coronary syndromes, there is a strong need for rapidly acting and reversible antiplatelet agents in order to minimize the risk of thrombotic events and bleeding complications. In this study, a series of new P(1),P(4)-di(adenosine-5') tetraphosphate (Ap4A) derivatives with modifications in the base and in the tetraphosphate chain were sy ...[more]