Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate.

ABSTRACT:

Background

Accumulating evidence suggests that chronic prostatic inflammation may lead to prostate cancer development. Growth differentiation factor-15 (GDF-15) is highly expressed in the prostate and has been associated with inflammation and tumorigenesis.

Methods

To examine the relationship between GDF-15 and prostatic inflammation, GDF-15 expression was measured by immunohistochemical (IHC) staining in human prostatectomy specimens containing inflammation. The relationship between GDF-15 and specific inflammatory cells was determined using non-biased computer image analysis. To provide insight into a potential suppressive role for GDF-15 in inflammation, activation of inflammatory mediator nuclear factor of kappa B (NFκB) was measured in PC3 cells.

Results

GDF-15 e

SUBMITTER: Lambert JR 

PROVIDER: S-EPMC4682671 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature