Dataset Information

Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study.

ABSTRACT:

Purpose

To investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population.

Methods

In 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOMA-IR. The association of HOMA-IR with IOP was assessed using a linear regression model, adjusted for age and possible risk factors that can elevate IOP.

Results

The mean IOP ± SD was 13.7 ± 2.7 mm Hg in the right eye and 13.6 ± 2.7 mm Hg in the left eye. After adjusting for age, sex, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, body mass index, waist circumference, smoking habits, alcohol intake, and regular exercise, increased HOMA-IR levels were significantly associated with increasing IOP (P < 0.05). In the subgroup analyses based on the presence or absence of possible confounding risk factors, there was no evidence of heterogeneity between all subgroups (P for heterogeneity > 0.08).

Conclusions

The HOMA-IR is independently associated with elevated IOP levels after adjustment for confounding factors.

SUBMITTER: Fujiwara K

PROVIDER: S-EPMC4684191 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Publications

Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study.

Fujiwara Kohta K Yasuda Miho M Ninomiya Toshiharu T Hata Jun J Hashimoto Sawako S Yoshitomi Takeshi T Kiyohara Yutaka Y Ishibashi Tatsuro T

Investigative ophthalmology & visual science 20151201 13

<h4>Purpose</h4>To investigate association of the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate index of insulin resistance, with IOP in a general Japanese population.<h4>Methods</h4>In 2007, a total of 3119 Japanese community-dwellers, aged 40 years or older, underwent eye examinations, including IOP measurement with a noncontact tonometer. Of these, 2254 residents participated in this study. Fasting serum glucose and plasma insulin were measured to determine the HOM ...[more]

PMID: 26720445

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Dataset Information

Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study.

Purpose

Methods

Results

Conclusions

Publications

Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study.

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