Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study.

ABSTRACT:

Context

In trials, thiazolidinediones (TZDs) increase fracture risk in women, but the effects of discontinuation are unknown.

Objective

The objective was to investigate the effects of TZD use and discontinuation on fractures in women and men.

Design

This was a longitudinal observational cohort study using data from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial bone ancillary study. Duration of TZD use and discontinuation during ACCORD, assessed every 2-4 months at clinic visits, were modeled as time-varying covariates in proportional hazards models for occurrence of first non-spine fracture.

Participants

We studied a total of 6865 participants in ACCORD BONE.

Main outcome measures

Main outcome measures were centrally adjudicated no

SUBMITTER: Schwartz AV 

PROVIDER: S-EPMC4702444 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature