Dataset Information

Biomarkers of Vitamin D Status and Risk of ESRD.

ABSTRACT:

Background

Disordered mineral metabolism is characteristic of decreased kidney function. However, the prospective associations between circulating levels of vitamin D binding protein, vitamin D, and end-stage renal disease (ESRD) have not been extensively evaluated in epidemiologic studies.

Study design

Nested case-control study.

Setting & participants

Middle-aged black and white men and women from 4 US communities.

Predictors

Baseline levels of vitamin D binding protein, 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH]2D) were measured in blood samples collected at study visit 4 (1996-1998) of the ARIC (Atherosclerosis Risk in Communities) Study.

Outcome

ESRD cases (n=184) were identified through hospitalization diagnostic codes from 1996 to 2008 and were frequency matched to controls (n=251) on categories of estimated glomerular filtration rate, albuminuria, diabetes mellitus, sex, and race.

Measurements

Logistic regression was used to estimate the association between mineral metabolism biomarkers (vitamin D binding protein, 25(OH)D, and 1,25(OH)2D) and incident ESRD, adjusting for age, sex, race, estimated glomerular filtration rate, albuminuria, diabetes mellitus, hypertension, education, specimen type, and serum levels of calcium, phosphate, and parathyroid hormone.

Results

Higher vitamin D binding protein levels were associated with elevated risk for incident ESRD (OR, 1.76; 95% CI, 1.22-2.54; P=0.003). Higher free and bioavailable 25(OH)D levels were associated with reduced risk for incident ESRD (ORs of 0.65 [95% CI, 0.46-0.92; P=0.02] and 0.63 [95% CI, 0.43-0.91; P=0.02] for free and bioavailable 25[OH]D, respectively). There was no association between ESRD and overall levels of 25(OH)D (OR, 0.83; 95% CI, 0.58-1.19; P=0.3) or 1,25(OH)2D (OR, 0.73; 95% CI, 0.48-1.13; P=0.2).

Limitations

Lack of direct measurement of free and bioavailable vitamin D.

Conclusions

In the general population, blood levels of vitamin D binding protein were positively associated and blood levels of free and bioavailable 25(OH)D were inversely associated with new-onset ESRD during follow-up.

SUBMITTER: Rebholz CM

PROVIDER: S-EPMC4724452 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Publications

Biomarkers of Vitamin D Status and Risk of ESRD.

Rebholz Casey M CM Grams Morgan E ME Lutsey Pamela L PL Hoofnagle Andrew N AN Misialek Jeffrey R JR Inker Lesley A LA Levey Andrew S AS Selvin Elizabeth E Hsu Chi-Yuan CY Kimmel Paul L PL Vasan Ramachandran S RS Eckfeldt John H JH Coresh Josef J

American journal of kidney diseases : the official journal of the National Kidney Foundation 20151023 2

<h4>Background</h4>Disordered mineral metabolism is characteristic of decreased kidney function. However, the prospective associations between circulating levels of vitamin D binding protein, vitamin D, and end-stage renal disease (ESRD) have not been extensively evaluated in epidemiologic studies.<h4>Study design</h4>Nested case-control study.<h4>Setting & participants</h4>Middle-aged black and white men and women from 4 US communities.<h4>Predictors</h4>Baseline levels of vitamin D binding pro ...[more]

PMID: 26475393

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Dataset Information

Biomarkers of Vitamin D Status and Risk of ESRD.

Background

Study design

Setting & participants

Predictors

Outcome

Measurements

Results

Limitations

Conclusions

Publications

Biomarkers of Vitamin D Status and Risk of ESRD.

Similar Datasets

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