Biomarkers of Vitamin D Status and Risk of ESRD.

ABSTRACT:

Background

Disordered mineral metabolism is characteristic of decreased kidney function. However, the prospective associations between circulating levels of vitamin D binding protein, vitamin D, and end-stage renal disease (ESRD) have not been extensively evaluated in epidemiologic studies.

Study design

Nested case-control study.

Setting & participants

Middle-aged black and white men and women from 4 US communities.

Predictors

Baseline levels of vitamin D binding protein, 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH]2D) were measured in blood samples collected at study visit 4 (1996-1998) of the ARIC (Atherosclerosis Risk in Communities) Study.

Outcome

ESRD cases (n=184) were identified through hospitalization diagnostic codes from

SUBMITTER: Rebholz CM 

PROVIDER: S-EPMC4724452 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature