Ontology highlight
ABSTRACT:
SUBMITTER: Chin DW
PROVIDER: S-EPMC4742622 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Blood cancer journal 20160108
RUNX1/AML1 is among the most commonly mutated genes in human leukemia. Haploinsufficiency of RUNX1 causes familial platelet disorder with predisposition to myeloid malignancies (FPD/MM). However, the molecular mechanism of FPD/MM remains unknown. Here we show that murine Runx1(+/-) hematopoietic cells are hypersensitive to granulocyte colony-stimulating factor (G-CSF), leading to enhanced expansion and mobilization of stem/progenitor cells and myeloid differentiation block. Upon G-CSF stimulatio ...[more]