Ontology highlight
ABSTRACT:
SUBMITTER: Long K
PROVIDER: S-EPMC4742793 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Long K K Moss L L Laursen L L Boulter L L Ffrench-Constant C C
Nature communications 20160203
Development of the cerebral cortex requires regulation of proliferation and differentiation of neural stem cells and a diverse range of progenitors. Recent work suggests a role for extracellular matrix (ECM) and the major family of ECM receptors, the integrins. Here we show that enhancing integrin beta-1 signalling, by expressing a constitutively active integrin beta-1 (CA*β1) in the embryonic chick mesencephalon, enhances neurogenesis and increases the number of mitotic cells dividing away from ...[more]