Echinococcus granulosus Antigen B binds to monocytes and macrophages modulating cell response to inflammation.

ABSTRACT:

Background

Antigen B (EgAgB) is an abundant lipoprotein released by the larva of the cestode Echinococcus granulosus into the host tissues. Its protein moiety belongs to the cestode-specific family known as hydrophobic ligand binding protein (HLBP), and is encoded by five gene subfamilies (EgAgB8/1-EgAgB8/5). The functions of EgAgB in parasite biology remain unclear. It may play a role in the parasite's lipid metabolism since it carries host lipids that E. granulosus is unable to synthesise. On the other hand, there is evidence supporting immuno-modulating activities in EgAgB, particularly on innate immune cells. Both hypothetical functions might involve EgAgB interactions with monocytes and macrophages, which have not been formally analysed yet.

Methods

EgAgB binding to mon

SUBMITTER: Silva-Alvarez V 

PROVIDER: S-EPMC4743400 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature