A 1.8-kb insertion in the 3'-UTR of RXFP2 is associated with polledness in sheep.
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ABSTRACT:
SUBMITTER: Wiedemar N
PROVIDER: S-EPMC4744954 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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A 1.8-kb insertion in the 3'-UTR of RXFP2 is associated with polledness in sheep.
Wiedemar Natalie N Drögemüller Cord C
Animal genetics 20150623 4
Sheep breeds show a broad spectrum of different horn phenotypes. In most modern production breeds, sheep are polled (absence of horns), whereas horns occur mainly in indigenous breeds. Previous studies mapped the responsible locus to the region of the RXFP2 gene on ovine chromosome 10. A 4-kb region of the 3'-end of RXFP2 was amplified in horned and polled animals from seven Swiss sheep breeds. Sequence analysis identified a 1833-bp genomic insertion located in the 3'-UTR region of RXFP2 present ...[more]
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