Ontology highlight
ABSTRACT:
SUBMITTER: Omoyinmi E
PROVIDER: S-EPMC4746827 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Pediatric rheumatology online journal 20160209 1
<h4>Background</h4>Various pathways involved in the pathogenesis of sJIA have been identified through gene expression profiling in peripheral blood mononuclear cells (PBMC), but not in neutrophils. Since neutrophils are important in tissue damage during inflammation, and are elevated as part of the acute phase response, we hypothesised that neutrophil pathways could also be important in the pathogenesis of sJIA. We therefore studied the gene profile in both PBMC and neutrophils of sJIA patients ...[more]