Genome-wide gene-gene interaction analysis for next-generation sequencing.

ABSTRACT: The critical barrier in interaction analysis for next-generation sequencing (NGS) data is that the traditional pairwise interaction analysis that is suitable for common variants is difficult to apply to rare variants because of their prohibitive computational time, large number of tests and low power. The great challenges for successful detection of interactions with NGS data are (1) the demands in the paradigm of changes in interaction analysis; (2) severe multiple testing; and (3) heavy computations. To meet these challenges, we shift the paradigm of interaction analysis between two SNPs to interaction analysis between two genomic regions. In other words, we take a gene as a unit of analysis and use functional data analysis techniques as dimensional reduction tools to develop a novel sta

SUBMITTER: Zhao J 

PROVIDER: S-EPMC4755380 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature