Ontology highlight
ABSTRACT:
SUBMITTER: Trego KS
PROVIDER: S-EPMC4761302 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Trego Kelly S KS Groesser Torsten T Davalos Albert R AR Parplys Ann C AC Zhao Weixing W Nelson Michael R MR Hlaing Ayesu A Shih Brian B Rydberg Björn B Pluth Janice M JM Tsai Miaw-Sheue MS Hoeijmakers Jan H J JHJ Sung Patrick P Wiese Claudia C Campisi Judith J Cooper Priscilla K PK
Molecular cell 20160128 4
XPG is a structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG mutations cause the skin cancer-prone syndrome xeroderma pigmentosum. Truncating mutations instead cause the neurodevelopmental progeroid disorder Cockayne syndrome, but little is known about how XPG loss results in this devastating disease. We identify XPG as a partner of BRCA1 and BRCA2 in maintaining genomic stability through homologous recombination (HRR). XPG depletion causes DNA dou ...[more]