Design and fine-tuning redox potentials of metalloproteins involved in electron transfer in bioenergetics.

ABSTRACT: Redox potentials are a major contributor in controlling the electron transfer (ET) rates and thus regulating the ET processes in the bioenergetics. To maximize the efficiency of the ET process, one needs to master the art of tuning the redox potential, especially in metalloproteins, as they represent major classes of ET proteins. In this review, we first describe the importance of tuning the redox potential of ET centers and its role in regulating the ET in bioenergetic processes including photosynthesis and respiration. The main focus of this review is to summarize recent work in designing the ET centers, namely cupredoxins, cytochromes, and iron-sulfur proteins, and examples in design of protein networks involved these ET centers. We then discuss the factors that affect redox potentials

SUBMITTER: Hosseinzadeh P 

PROVIDER: S-EPMC4761536 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature