Oxidized plasma albumin promotes platelet-endothelial crosstalk and endothelial tissue factor expression.

ABSTRACT: Plasma advanced oxidation protein products (AOPPs), a class of pro-inflammatory pathogenic mediators, accumulate in subjects with chronic kidney disease. Whether AOPPs contribute to coagulation abnormalities, which are frequently seen in uremic patients, is unknown. Here we report that AOPPs activate platelets via a CD36-mediated signaling pathway. Activation of signaling pathways by AOPP-platelet interaction resulted in the expression of several platelet activation markers and rapidly induced the expression of CD40 ligand, triggering platelet adhesion to endothelial cells and promoting endothelial tissue factor expression. AOPPs and serum tissue factor levels were considerably increased in end stage renal disease patients on hemodialysis and a significant correlation of AOPPs and serum ti

SUBMITTER: Pasterk L 

PROVIDER: S-EPMC4764952 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature