MSProGene: integrative proteogenomics beyond six-frames and single nucleotide polymorphisms.

ABSTRACT:

Unlabelled

Ongoing advances in high-throughput technologies have facilitated accurate proteomic measurements and provide a wealth of information on genomic and transcript level. In proteogenomics, this multi-omics data is combined to analyze unannotated organisms and to allow more accurate sample-specific predictions. Existing analysis methods still mainly depend on six-frame translations or reference protein databases that are extended by transcriptomic information or known single nucleotide polymorphisms (SNPs). However, six-frames introduce an artificial sixfold increase of the target database and SNP integration requires a suitable database summarizing results from previous experiments. We overcome these limitations by introducing MSProGene, a new method for integrative proteog

SUBMITTER: Zickmann F 

PROVIDER: S-EPMC4765881 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature