Ontology highlight
ABSTRACT:
SUBMITTER: Reyes-Robles T
PROVIDER: S-EPMC4772982 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Reyes-Robles Tamara T Lubkin Ashira A Alonzo Francis F Lacy D Borden DB Torres Victor J VJ
EMBO reports 20160208 3
Staphylococcus aureus (S. aureus) is a human pathogen that relies on the subversion of host phagocytes to support its pathogenic lifestyle. S. aureus strains can produce up to five beta-barrel, bi-component, pore-forming leukocidins that target and kill host phagocytes. Thus, preventing immune cell killing by these toxins is likely to boost host immunity. Here, we describe the identification of glycine-rich motifs within the membrane-penetrating stem domains of the leukocidin subunits that are c ...[more]