PPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice.

ABSTRACT:

Background

Several peroxisome proliferator-activated receptor (PPAR) agonists reduce voluntary alcohol consumption in rodent models, and evidence suggests that PPARα and γ subunits play an important role in this effect. To define the subunit dependence of this action, we tested selective PPARα and α/γ agonists and antagonists in addition to null mutant mice lacking PPARα.

Methods

The effects of fenofibrate (PPARα agonist) and tesaglitazar (PPARα/γ agonist) on continuous and intermittent 2-bottle choice drinking tests were examined in male and female wild-type mice and in male mice lacking PPARα. We compared the ability of MK886 (PPARα antagonist) and GW9662 (PPARγ antagonist) to inhibit the effects of fenofibrate and tesaglitazar in wild-type mice. The estrogen receptor anta

SUBMITTER: Blednov YA 

PROVIDER: S-EPMC4775296 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature