Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment.

ABSTRACT:

Background

There is increasing need for better therapies to prevent the development of heart failure after myocardial infarction (MI). An injectable hydrogel derived from decellularized porcine ventricular myocardium has been shown to halt the post-infarction progression of negative left ventricular remodeling and decline in cardiac function in both small and large animal models.

Objectives

This study sought to elucidate the tissue-level mechanisms underlying the therapeutic benefits of myocardial matrix injection.

Methods

Myocardial matrix or saline was injected into infarcted myocardium 1 week after ischemia-reperfusion in Sprague-Dawley rats. Cardiac function was evaluated by magnetic resonance imaging and hemodynamic measurements at 5 weeks after injection. Whole

SUBMITTER: Wassenaar JW 

PROVIDER: S-EPMC4779189 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature