Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation.

ABSTRACT:

Objective

To identify the clinical and radiologic features that should raise suspicion for the pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation (CAA-I).

Methods

We retrospectively reviewed the characteristics of 5 newly diagnosed and 23 previously reported patients in whom the CAA-I imaging findings were initially interpreted as CNS neoplasms.

Results

Most cases (85%) occurred in patients >60 years old. The clinical characteristics at presentation included subacute cognitive decline (50%), confusion (32%), focal deficits (32%), seizures (25%), and headaches (21%). Brain MRI demonstrated infiltrative white matter lesions that exhibited a loco-regional mass effect without parenchymal enhancement (93%). In general, these findings were interp

SUBMITTER: Ronsin S 

PROVIDER: S-EPMC4782113 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature