Effect of long-term antibiotic use on weight in adolescents with acne.

ABSTRACT:

Objectives

Antibiotics increase weight in farm animals and may cause weight gain in humans. We used electronic health records from a large primary care organization to determine the effect of antibiotics on weight and BMI in healthy adolescents with acne.

Methods

We performed a retrospective cohort study of adolescents with acne prescribed ≥4 weeks of oral antibiotics with weight measurements within 18 months pre-antibiotics and 12 months post-antibiotics. We compared within-individual changes in weight-for-age Z-scores (WAZs) and BMI-for-age Z-scores (BMIZs). We used: (i) paired t-tests to analyse changes between the last pre-antibiotics versus the first post-antibiotic measurements; (ii) piecewise-constant-mixed models to capture changes between mean measurements pre- vers

SUBMITTER: Contopoulos-Ioannidis DG 

PROVIDER: S-EPMC4790625 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature