Ontology highlight
ABSTRACT:
SUBMITTER: Houtepen LC
PROVIDER: S-EPMC4802173 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature communications 20160321
DNA methylation likely plays a role in the regulation of human stress reactivity. Here we show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a locus in the Kit ligand gene (KITLG; cg27512205) showed the strongest association with cortisol stress reactivity (P=5.8 × 10(-6)). Replication was obtained in two independent samples using either blood (N=45, P=0.001) or buccal cells (N=255, P=0.004). KITLG methylation strongly mediates the relationship between childh ...[more]