Ontology highlight
ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC4808003 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Qin Yong Y Tang Bo B Hu Chang-Jiang CJ Xiao Yu-Feng YF Xie Rui R Yong Xin X Wu Yu Yun YY Dong Hui H Yang Shi-Ming SM
Oncotarget 20160101 1
In human cancer, high telomerase expression is correlated with tumor aggressiveness and metastatic potential. Telomerase activation occurs through telomerase reverse transcriptase (hTERT) induction, which contributes to malignant transformation by stabilizing telomeres. Previous studies have shown that hTERT can promote tumor invasion and metastasis of gastric cancer, liver cancer and esophageal cancer. Epithelial-to-mesenchymal transition (EMT), a requirement for tumor invasion and metastasis, ...[more]