Unknown

Dataset Information

0

An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer.


ABSTRACT: In human cancer, high telomerase expression is correlated with tumor aggressiveness and metastatic potential. Telomerase activation occurs through telomerase reverse transcriptase (hTERT) induction, which contributes to malignant transformation by stabilizing telomeres. Previous studies have shown that hTERT can promote tumor invasion and metastasis of gastric cancer, liver cancer and esophageal cancer. Epithelial-to-mesenchymal transition (EMT), a requirement for tumor invasion and metastasis, plays a key role in cancer progression. Although hTERT promotes EMT through Wnt signaling in several cancers, it is unknown if other signaling pathways are involved. In the present study, we found that hTERT and ZEB1 form a complex, which directly binds to the E-cadherin promoter, and then inhibits E-cadherin expression and promots EMT in colorectal cancer cells. hTERT overexpression in HCT116 and SW480 cells could induce E-cadherin down-regulation. However, E-cadherin expression was recovered when ZEB1 function was impaired even during hTERT overexpression. Taken together, our findings suggest that hTERT can promote cancer metastasis by stimulating EMT through the ZEB1 pathway and therefore inhibiting them may prevent cancer progression.

SUBMITTER: Qin Y 

PROVIDER: S-EPMC4808003 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

An hTERT/ZEB1 complex directly regulates E-cadherin to promote epithelial-to-mesenchymal transition (EMT) in colorectal cancer.

Qin Yong Y   Tang Bo B   Hu Chang-Jiang CJ   Xiao Yu-Feng YF   Xie Rui R   Yong Xin X   Wu Yu Yun YY   Dong Hui H   Yang Shi-Ming SM  

Oncotarget 20160101 1


In human cancer, high telomerase expression is correlated with tumor aggressiveness and metastatic potential. Telomerase activation occurs through telomerase reverse transcriptase (hTERT) induction, which contributes to malignant transformation by stabilizing telomeres. Previous studies have shown that hTERT can promote tumor invasion and metastasis of gastric cancer, liver cancer and esophageal cancer. Epithelial-to-mesenchymal transition (EMT), a requirement for tumor invasion and metastasis,  ...[more]

Similar Datasets

| S-EPMC3516763 | biostudies-literature
| S-EPMC3285352 | biostudies-literature
2012-10-25 | E-GEOD-41802 | biostudies-arrayexpress
2012-10-25 | GSE41802 | GEO
| S-EPMC3228467 | biostudies-other
| S-EPMC2507753 | biostudies-literature
| S-EPMC3787864 | biostudies-literature
| S-EPMC5004933 | biostudies-literature
| S-EPMC5342558 | biostudies-literature
| S-EPMC6606042 | biostudies-literature