Ontology highlight
ABSTRACT:
SUBMITTER: Yan L
PROVIDER: S-EPMC4813467 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20151230 9
The epigenetic regulation of spatiotemporal gene expression is crucial for human development. Here, we present whole-genome chromatin immunoprecipitation followed by high throughput DNA sequencing (ChIP-seq) analyses of a wide variety of histone markers in the brain, heart, and liver of early human embryos shortly after their formation. We identified 40,181 active enhancers, with a large portion showing tissue-specific and developmental stage-specific patterns, pointing to their roles in control ...[more]