Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.

ABSTRACT:

Background

Meningiomas are the most common primary intracranial tumor in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of targeted therapies for some patients. The frequency of such mutations in clinical cohorts and the presence of other actionable mutations in meningiomas are important to define.

Methods

We used high-resolution array-comparative genomic hybridization to prospectively characterize copy-number changes in 150 meningiomas and then characterized these samples for mutations in AKT1, KLF4, NF2, PIK3CA, SMO, and TRAF7.

Results

Similar to prior reports, we identified AKT1 and SMO mutations in a subset of non-NF2-mutant meningiomas (ie, ∼9% and ∼6%, respectively). Notably, we detected oncogenic mutations in PIK3CA i

SUBMITTER: Abedalthagafi M 

PROVIDER: S-EPMC4827048 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature