Longitudinal relationships among biomarkers for Alzheimer disease in the Adult Children Study.

ABSTRACT:

Objective

To determine whether and how longitudinal rates of change in MRI volumetrics, CSF concentrations of Alzheimer-related proteins, molecular imaging of cerebral fibrillar amyloid with PET using the [(11)C] benzothiazole tracer, Pittsburgh compound B (PiB), and cognition were associated among asymptomatic middle-aged to older individuals.

Methods

Multivariate mixed models for repeated measures were used to assess the correlations on the rates of changes across markers.

Results

Among 209 asymptomatic middle-aged to older individuals longitudinally followed for up to 11 years (mean 6.7 years), a faster intraindividual decrease in CSF Aβ42 was associated with a faster increase in PiB mean cortical standardized uptake value ratio (MCSUVR, p = 0.04), but not others.

SUBMITTER: Xiong C 

PROVIDER: S-EPMC4836885 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature