Ontology highlight
ABSTRACT:
SUBMITTER: Ackema KB
PROVIDER: S-EPMC4839682 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20160421 4
Endoplasmic reticulum (ER)-mitochondrial contact sites play a pivotal role in exchange of lipids and ions between the two organelles. How size and function of these contact sites are regulated remains elusive. Here we report a previously unanticipated, but conserved role of the small GTPase Sar1 in the regulation of ER-mitochondrial contact site size. Activated Sar1 introduces membrane curvature through its N-terminal amphiphatic helix at the ER-mitochondria interphase and thereby reducing conta ...[more]