Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and Western countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD; nonetheless, the effect of inter-individual differences in the normal liver epigenome with regard to the susceptibility to NAFLD has not been determined.

Results

In the present study, we investigated the association between the DNA methylation status in the livers of A/J and WSB/EiJ mice and the severity of NAFLD-associated liver injury. We demonstrate that A/J and WSB/EiJ mice, which are characterized by significant differences in the severity of liver injury induced by a choline- and folate-deficient (CFD) diet exhibit substantia

SUBMITTER: Tryndyak VP 

PROVIDER: S-EPMC4840954 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature