Variation in Cancer Incidence among Patients with ESRD during Kidney Function and Nonfunction Intervals.

ABSTRACT: Among patients with ESRD, cancer risk is affected by kidney dysfunction and by immunosuppression after transplant. Assessing patterns across periods of dialysis and kidney transplantation may inform cancer etiology. We evaluated 202,195 kidney transplant candidates and recipients from a linkage between the Scientific Registry of Transplant Recipients and cancer registries, and compared incidence in kidney function intervals (time with a transplant) with incidence in nonfunction intervals (waitlist or time after transplant failure), adjusting for demographic factors. Incidence of infection-related and immune-related cancer was higher during kidney function intervals than during nonfunction intervals. Incidence was most elevated for Kaposi sarcoma (hazard ratio [HR], 9.1; 95% confidence inte

SUBMITTER: Yanik EL 

PROVIDER: S-EPMC4849829 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature