BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants.

ABSTRACT:

Objective

To conduct a systematic review and meta-analysis of cohort studies of body mass index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the dose-response curve, and the influence on the results of confounding from smoking, weight loss associated with disease, and preclinical disease.

Data sources

PubMed and Embase databases searched up to 23 September 2015.

Study selection

Cohort studies that reported adjusted risk estimates for at least three categories of BMI in relation to all cause mortality.

Data synthesis

Summary relative risks were calculated with random effects models. Non-linear associations were explored with fractional polynomial models.

Results

230 cohort studies (207 publications) were included. T

SUBMITTER: Aune D 

PROVIDER: S-EPMC4856854 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature