Lactation undernutrition leads to multigenerational molecular programming of hypothalamic gene networks controlling reproduction.

ABSTRACT:

Background

Reproductive success is dependent on development of hypothalamic circuits involving many hormonal systems working in concert to regulate gonadal function and sexual behavior. The timing of pubertal initiation and progression in mammals is likely influenced by the nutritional and metabolic state, leading us to the hypothesis that transient malnutrition experienced at critical times during development may perturb pubertal progression through successive generations. To test this hypothesis we have utilized a mouse model of undernutrition during suckling by exposing lactating mothers to undernutrition.

Results

Using a combination of transcriptomic and biological approaches, we demonstrate that molecular programming of hypothalamus may perturb gender specific phenotype

SUBMITTER: Kaczmarek MM 

PROVIDER: S-EPMC4857247 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature