Dataset Information
Interleukin-25 is detrimental for recovery after spinal cord injury in mice.
Ontology highlight
ABSTRACT: Background
The cytokine, interleukin (IL)-25, is thought to be critically involved in inducing a type 2 immune response which may contribute to regeneration after central nervous system (CNS) trauma. We investigated whether applying recombinant IL-25, locally or systemically, in a mouse model of spinal cord injury (SCI) improves functional and histological recovery.Findings
Repeated systemic administration of IL-25 did not influence functional recovery following SCI. In contrast, a single local administration of IL-25 significantly worsened locomotor outcome, which was evident from a decreased Basso mouse scale (BMS) score compared with phosphate-buffered saline (PBS)-treated controls. This was accompanied by a significant increase in lesion size, demyelination, and T helper cell infiltration.Conclusions
These data show for the first time that IL-25 is either ineffective when applied systemically or detrimental to spinal cord recovery when applied locally. Our findings question the potential neuroprotective role of IL-25 following CNS trauma.
SUBMITTER: Dooley D
PROVIDER: S-EPMC4858907 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Interleukin-25 is detrimental for recovery after spinal cord injury in mice.
Journal of neuroinflammation 20160506 1
<h4>Background</h4>The cytokine, interleukin (IL)-25, is thought to be critically involved in inducing a type 2 immune response which may contribute to regeneration after central nervous system (CNS) trauma. We investigated whether applying recombinant IL-25, locally or systemically, in a mouse model of spinal cord injury (SCI) improves functional and histological recovery.<h4>Findings</h4>Repeated systemic administration of IL-25 did not influence functional recovery following SCI. In contrast, ...[more]