Lack of autophagy induces steroid-resistant airway inflammation.

ABSTRACT:

Background

Neutrophilic corticosteroid-resistant asthma accounts for a significant proportion of asthma; however, little is known about the mechanisms that underlie the pathogenesis of the disease.

Objective

We sought to address the role of autophagy in lung inflammation and the pathogenesis of corticosteroid-resistant neutrophilic asthma.

Methods

We developed CD11c-specific autophagy-related gene 5 (Atg5)(-/-) mice and used several murine models to investigate the role of autophagy in asthmatic patients.

Results

For the first time, we found that deletion of the Atg5 gene specifically in CD11c(+) cells, which leads to impairment of the autophagy pathway, causes unprovoked spontaneous airway hyperreactivity and severe neutrophilic lung inflammation in mice. We f

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC4860134 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature