Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus.

ABSTRACT: The esophageal submucosal glands (SMG) protect the squamous epithelium from insults such as gastroesophageal reflux disease by secreting mucins and bicarbonate. We have observed metaplastic changes within the SMG acini that we have termed oncocytic glandular metaplasia (OGM), and necrotizing sialometaplasia-like change (NSMLC). The aim of this study is to evaluate the associated clinicopathological parameters of, and to phenotypically characterize the SMG metaplasias. Esophagectomy specimens were retrospectively assessed on hematoxylin and eosin sections and assigned to either a Barrett's esophagus (BE) or non-BE control group. Clinicopathologic data was collected, and univariate analysis and multivariate logistic regression models were performed to assess the adjusted associations with NS

SUBMITTER: Braxton DR 

PROVIDER: S-EPMC4868088 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature