An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma.

ABSTRACT:

Background

The prognosis of children with metastatic stage 4 neuroblastoma (NB) has remained poor in the past decade.

Patients and methods

Using microarray analyses of 342 primary tumors, we here developed and validated an easy to use gene expression-based risk score including 18 genes, which can robustly predict the outcome of stage 4 patients.

Results

This classifier was a significant predictor of overall survival in two independent validation cohorts [cohort 1 (n = 214): P = 6.3 × 10(-5); cohort 2 (n = 27): P = 3.1 × 10(-2)]. The prognostic value of the risk score was validated by multivariate analysis including the established markers age and MYCN status (P = 0.027). In the pooled validation cohorts (n = 241), integration of the risk score with the age and/or MYCN

SUBMITTER: Formicola D 

PROVIDER: S-EPMC4870777 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature