Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study.

ABSTRACT:

Purpose

The International Neuroblastoma Response Criteria (INRC) require serial measurements of primary tumors in three dimensions, whereas the Response Evaluation Criteria in Solid Tumors (RECIST) require measurement in one dimension. This study was conducted to identify the preferred method of primary tumor response assessment for use in revised INRC.

Patients and methods

Patients younger than 20 years with high-risk neuroblastoma were eligible if they were diagnosed between 2000 and 2012 and if three primary tumor measurements (antero-posterior, width, cranio-caudal) were recorded at least twice before resection. Responses were defined as ≥ 30% reduction in longest dimension as per RECIST, ≥ 50% reduction in volume as per INRC, or ≥ 65% reduction in volume.

Results

SUBMITTER: Bagatell R 

PROVIDER: S-EPMC4872026 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature