Ontology highlight
ABSTRACT:
SUBMITTER: Moutsianas L
PROVIDER: S-EPMC4874245 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20150907 10
Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence ...[more]