Dataset Information
Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
Ontology highlight
ABSTRACT: Objectives
To determine whether moderate-intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants.Design
Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years.Setting
Eight field centers.Participants
Sedentary men and women aged 70-89 with lower extremity physical limitations but able to walk 400-m in 15 minutes or less (N = 1,635).Interventions
Structured, moderate-intensity PA (n = 818) at a center (2×/wk) and at home (3-4×/wk) that included aerobic, strength, balance, and flexibility training or HE (n = 817) of educational workshops and upper extremity stretching exercises.Measurements
All-cause inpatient hospitalizations ascertained at 6-month intervals.Results
There were 1,458 hospitalizations (49.1% of PA, 44.4% of HE; risk difference = 4.68%, 95% confidence interval (CI) = -0.18-9.54; hazard ratio (HR) = 1.16, 95% CI = 1.00-1.34). The intervention effect on incident hospitalization did not differ according to race, sex, Short Physical Performance Battery score, age, or history of cardiovascular disease or diabetes mellitus. PA was associated with higher rates of hospitalization in the middle baseline gait speed category, than HE (<0.8 m/s: HR = 0.93, 95% CI = 0.76-1.14; 0.8-1.0 m/s: HR = 1.54, 95% CI = 1.23-1.94; >1.0 m/s: HR = 1.05, 95% CI = 0.67-1.65; interaction P = .005).Conclusion
A PA program in older adults at risk for mobility disability did not lead to a different risk of specific types of hospitalizations than a HE program overall. Baseline gait speed may be a marker for risk of hospitalization during a PA intervention, because individuals with moderate baseline gait speed in the PA group had slightly higher rates of hospitalization than those in the HE group.Trial registration
ClinicalTrials.gov identifier: NCT01072500.
SUBMITTER: Marsh AP
PROVIDER: S-EPMC4887151 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
Journal of the American Geriatrics Society 20160501 5
<h4>Objectives</h4>To determine whether moderate-intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants.<h4>Design</h4>Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years.<h4>Setting</h4>Eight field centers.<h4>Participants</h4>Sedentary men and women aged 70-89 with lower extremity physical limitations but able to walk 400 ...[more]