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The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain.

ABSTRACT: We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

SUBMITTER: Ren W 

PROVIDER: S-EPMC4889808 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain.

Ren Wenjie W   Centeno Maria Virginia MV   Berger Sara S   Wu Ying Y   Na Xiaodong X   Liu Xianguo X   Kondapalli Jyothisri J   Apkarian A Vania AV   Martina Marco M   Surmeier D James DJ  

Nature neuroscience 20151221 2

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nocicep  ...[more]

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