Estrogen receptor beta as a prognostic factor in breast cancer patients: A systematic review and meta-analysis.

ABSTRACT:

Background

The prognostic role of estrogen receptor beta (ERβ) in early-stage breast cancer is unclear. We performed a systematic review and meta-analysis to evaluate the prognostic value of ERβ in early-stage breast cancer patients.

Method

We searched Medline, Embase, and the Web of Science for studies published between 1990 and 2015 that assessed ERβ status in breast cancer patients. A total of 25 studies comprising 9919 patients fitting our inclusion and exclusion criteria were included. The hazard ratios of ERβ status were extracted for diseases free survival (DFS)/ ) and overall survival (OS). Random or fixed-effects models were used when appropriate, and between-study heterogeneity was assessed.

Results

In the 20 studies that assessed ERβ status using immunohist

SUBMITTER: Tan W 

PROVIDER: S-EPMC4891126 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature