A prospective study of soluble receptor for advanced glycation end-products and colorectal cancer risk in postmenopausal women.

ABSTRACT:

Objectives

Receptor for advanced glycation end products (RAGE) expressed on adipocytes and immune cells can bind to ligand N(ε)-(carboxymethyl)-lysine (CML) and trigger dysregulation of adipokines and chronic inflammation. Soluble RAGE (sRAGE) mitigates the detrimental effect of RAGE. We examined the associations between circulating levels of CML-AGE and sRAGE and colorectal cancer (CRC).

Methods

In a case-cohort study of the Women's Health Initiative Study, blood levels of CML-AGE and sRAGE were measured using ELISA. We used multivariable Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident CRC in relation to quartiles (Q) of biomarker levels.

Results

Average follow-up was 7.8 years for 444 cases and 805 subcohort member

SUBMITTER: Chen L 

PROVIDER: S-EPMC4899266 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature