Advances in the prevention and treatment of congenital cytomegalovirus infection.

ABSTRACT:

Purpose of review

Cytomegalovirus (CMV) is the most common cause of congenital infection in the world. Symptomatic infants are at increased risk of developing permanent sequelae, including sensorineural hearing loss and neurodevelopmental delay. Advances in the treatment and prevention of congenital CMV infection are a high priority nationally and globally.

Recent findings

In symptomatic infants, antiviral therapy with 6 months of oral valganciclovir improves hearing and neurodevelopmental outcomes. Strategies to prevent congenital or maternal CMV infections, including the use of CMV hyperimmune globulin and development of a maternal vaccine, have yet to yield positive results.

Summary

The clinical significance of congenital CMV infection, developments in antiviral th

SUBMITTER: James SH 

PROVIDER: S-EPMC4908547 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature