HESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation.

ABSTRACT: Stem cell therapies for neurological disorders are rapidly moving towards use in clinical trials. Before initiation of clinical trials, extensive pre-clinical validation in appropriate animal models is essential. However, grafts of human cells into the rodent brain are rejected within weeks after transplantation and the standard methods of immune-suppression for the purpose of studying human xenografts are not always sufficient for the long-term studies needed for transplanted human neurons to maturate, integrate and provide functional benefits in the host brain. Neonatal injections in rat pups using human fetal brain cells have been shown to desensitise the host to accept human tissue grafts as adults, whilst not compromising their immune system. Here, we show that differentiated human em

SUBMITTER: Heuer A 

PROVIDER: S-EPMC4920671 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature