Non-hematopoietic effects of endogenous erythropoietin on lean mass and body weight regulation.

ABSTRACT:

Objective

To investigate the concurrent relationships between human plasma erythropoietin concentrations and energy expenditure (EE), body composition, plasma leptin concentrations, and associations with weight change.

Methods

Plasma to measure erythropoietin and leptin; data for body composition; 24-h EE measured in a whole-room calorimeter; and 75 g oral glucose tolerance testing were available from 109 full-heritage Pima Indians (55% male) from a larger study designed to understand the causes of obesity. Seventy-nine subjects had data for weight at a later visit (mean follow-up = 4.3 ± 1.9 years) to calculate percent weight change per year.

Results

Erythropoietin, adjusted for covariates, correlated with 24-h EE (r = 0.26, P = 0.007), sleeping EE (r = 0.29, P = 0.0

SUBMITTER: Reinhardt M 

PROVIDER: S-EPMC4925195 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature