Ontology highlight
ABSTRACT:
SUBMITTER: Lu F
PROVIDER: S-EPMC4946168 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cancer cell 20160501 5
Malignant gliomas exhibit extensive heterogeneity and poor prognosis. Here we identify mitotic Olig2-expressing cells as tumor-propagating cells in proneural gliomas, elimination of which blocks tumor initiation and progression. Intriguingly, deletion of Olig2 resulted in tumors that grow, albeit at a decelerated rate. Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis. Olig2 deletion causes a tumor phenot ...[more]