Project description:Acute myeloid leukemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation which gives rise to the RUNX1/ETO fusion protein and initiates the most common form of human AML. To understand the molecular principles governing this differential action, we used the differentiation of mouse embryonic stem cells expressing an inducible RUNX1/ETO protein into blood cells as a traceable model combined with genome-wide analyses of transcription factor binding and gene expression. We found that RUNX1/ETO interferes with both the activating and repressive function of its normal counterpart, RUNX1, at early and late stages of blood cell development. However, the response of the transcriptional network to RUNX1/ETO expression is stage-specific, highlighting the molecular mechanisms determining specific target cell expansion after an oncogenic hit.

2015-08-26 | GSE64589 | GEO

Ffar2 expression regulates leukaemic cell growth in vivo.

Project description: Not available

| S-EPMC5672929 | biostudies-literature

Cell stage dependent transcriptional response to leukaemic oncogene expression

2015-08-26 | E-GEOD-64589 | biostudies-arrayexpress

BCP

Project description:Genome of Paramecium aurelia species

| PRJEB40886 | ENA

Comparison of human BCP-ALL MLL-r and normal CD19+CD10+ precursor B-cell transcriptomes

Project description:B-cell precursor acute lymphoblastic leukemia (pre-B ALL) with mixed-lineage leukemia gene rearrangement (MLL-r) is a poor-prognosis subtype for which additional therapeutic targets are needed. We evaluated the glycomes, transcriptomes and proteomes of the same samples using only about 10^6 cells for each assay. We found that the expression of many genes involved in glycosylation differ between MLL-r cells and normal controls: 61 of the 221 human glycosyltransferases were differentially expressed in MLL-r cells. The leukemia cell glycome and many proteins associated with glycan biosynthesis were also significantly changed compared to normal control precursor B-cells, indicating that the malignant phenotype of these cells could be regulated by such changes.

2021-10-13 | GSE176364 | GEO

Area dependent behavior of bathocuproine (BCP) as cathode interfacial layers in organic photovoltaic cells.

Project description: Not available

| S-EPMC6105677 | biostudies-literature

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients.

Project description: Not available

| S-EPMC4359315 | biostudies-literature