Profile of the Spleen Transcriptome in Beef Steers with Variation in Gain and Feed Intake.

ABSTRACT: We have previously identified components of the immune system contributing to feed intake and gain in both the rumen and small intestine of beef steers. In this study, we examined the spleen, a major lymphatic organ near the digestive tract, to determine whether it was also influencing individual feed efficiency status through immune responses. Animals (n = 16) that were divergent for gain and intake were selected for tissue sampling. The spleen transcriptomes were evaluated by microarray. A total of 1216 genes were identified as differentially expressed. Genes were over-represented in Kyoto encyclopedia of genes and genomes (KEGG) pathways including biological regulation, protein folding, cell communication, immune systems process, response to stress, and RNA metabolic process. Several st

SUBMITTER: Lindholm-Perry AK 

PROVIDER: S-EPMC4958634 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature